Test Directory

PML::RARA t(15;17)(q22;q21) Diagnostic (AML)

Containers - Adult

Red Cap Tube EDTA KE 9ml
Volume Range

10-15ml Peripheral blood or Bone marrow specimen

Additive per Container


Laboratory Site

Crewe Road South
Telephone: 0131 537 1000

Transport arrangements

Blood and bone marrow specimens should ideally arrive within 24 hours of collection (maximum of 48 hours).  Specimens should arrive no later than 3.30pm on Friday.  Samples should be sent to the following address:

Western General Hospital

Haematology/Biochemistry Combined Reception

Immunophenotyping Laboratory

Crewe Road


EH4 2XU​


See also Specimen transportation.

Sample storage arrangements

Samples should be stored at room temperature. See specimen requirements.​

How to request

Please refer to our detailed requestinginstructions.  The HMDS request form can be located here.​ 


Testing may be performed by reflex from immunophenotyping.


Monday-Friday 9am-5pm

Anticipated turnaround

Results for diagnostic samples should be expected within 3 working days.  See results.

What happens if the result is positive or abnormal

The requesting clinician will be contacted where results are clinically significant. Please ensure details are included on request form.

Static information/disclaimer

This test is accredited to ISO 15189:2012

General additional information

​Full AML panel testing will be performed on all patients <70 years old diagnosed with AML based on immunophenotyping results via a reflex testing stra​tegy. 

Please see PML::RARA MRD monitoring for follow up samples.

The PML::RARA rearrangement is present approximately in 98% of acute promyelocytic leukaemia (APL) cases and defines a diagnosis of APL regardless of blast percentage. APL is considered to have a favourable prognosis when treated with all-trans-retinoic acid in combination with arsenic trioxide.

PML-RARA fusion gene analysis is carried out as part of the AML testing panel, which also includes CBFB::MYH11, BCR::ABL1, RUNX1::RUNX1T1, KMT2A fusion gene, FLT3 (ITD and D835 point mutation) and NPM1 gene mutation analysis.

For clinical advice on appropriate investigations and advice for the interpretation of test results, please contact us​.