Test Directory

NPM1

Containers - Adult

Red Cap Tube EDTA KE 2.7ml	Volume Range 10-15 ml peripheral blood, bone marrow specimen or FFPE tissue Additive per Container EDTA

Laboratory Site

WGH

Crewe Road South
Edinburgh
EH4 2XU

Telephone: 0131 537 1000

Transport arrangements

Specimens should ideally arrive within 24 hours of collection (maximum of 48 hours) and should be sent to the following address:

Western General Hospital

Haematology/Biochemistry Combined Reception

Immunophenotyping Laboratory

Crewe Road

Edinburgh

EH4 2XU

Sample storage arrangements

Samples should be stored at room temperature. See specimen requirements.

How to request

Please refer to our detailed requesting instructions. The HMDS request form can be located here.

HMDS request form PDF_v5.pdf

Availability

Monday-Friday 9am-5pm

Anticipated turnaround

Results should be expected within 10 working days. See results.

Static information/disclaimer

NPM1 gene mutation analysis performed for all patients diagnosed with AML based on immunophenotyping results via a reflex testing strategy.

Currently NPM1 MRD monitoring test is not performed.

This test is accredited to ISO 15189:2012

General additional information

Mutation in NPM1 gene is observed in approximately 30% of AML cases and is frequently associated with a normal karyotype. The presence of a NPM1 mutation in the absence of a FLT3 internal tandem duplication (or low level allele ratio) is associated with a more favourable prognosis in AML.

FLT3 (ITD and D835) mutation detection is also available for AML patients at diagnosis.

For clinical advice on appropriate investigations and advice for the interpretation of test results, please contact us.