Containers - Adult
Red Cap Tube EDTA KE 2.7ml
10-15 ml peripheral blood, bone marrow specimen or FFPE tissue
Additive per Container
Specimens should ideally arrive within 24 hours of collection (maximum of 48 hours) and should be sent to the following address:
Western General Hospital
Haematology/Biochemistry Combined Reception
See also Specimen transportation.
Sample storage arrangements
Samples should be stored at room temperature. See specimen requirements.
How to request
Please refer to our detailed requesting instructions. The HMDS request form can be located here.
Results should be expected within 10 working days. See results.
NPM1 gene mutation analysis performed for all patients diagnosed with AML based on immunophenotyping results via a reflex testing strategy.
Currently NPM1 MRD monitoring test is not performed.
This test is accredited to ISO 15189:2012
General additional information
Mutation in NPM1 gene is observed in approximately 30% of AML cases and is frequently associated with a normal karyotype. The presence of a NPM1 mutation in the absence of a FLT3 internal tandem duplication (or low level allele ratio) is associated with a more favourable prognosis in AML.
FLT3 (ITD and D835) mutation detection is also available for AML patients at diagnosis.
For clinical advice on appropriate investigations and advice for the interpretation of test results, please contact us.