Test Directory

NPM1

Containers - Adult

RedCapTubeEDTAKE2.7ml.jpg
Red Cap Tube EDTA KE 2.7ml
Volume Range

10-1​5 ml peripheral blood, bone marrow specimen or FFPE tissue

Additive per Container

​EDTA

Laboratory Site

WGH
Crewe Road South
Edinburgh
EH4 2XU
Telephone: 0131 537 1000

Transport arrangements

Specimens should ideally arrive within 24 hours of collection (maximum of 48 hours) and should be sent to the following address:

Western General Hospital

Haematology/Biochemistry Combined Reception

Immunophenotyping Laboratory

Crewe Road

Edinburgh

EH4 2XU​

 

See also Specimen transportation.

Sample storage arrangements

Samples should be stored at room temperature. See specimen requirements.​

How to request

Please refer to our detailed requesting ​instructions.  The HMDS request form can be located here.​

 

Availability

​Monday-Friday 9am-5pm

Anticipated turnaround

Results should be expected within 10 working days.  See results.

Static information/disclaimer

NPM1 gene mutation analysis performed for all patients diagnosed with AML based on immunophenotyping results via a reflex testing strategy.

Currently NPM1 MRD monitoring test is not performed.

 

This test is accredited to ISO 15189:2012

General additional information

Mutation in NPM1 gene is observed in approximately 30% of AML cases and is frequently associated with a normal karyotype. The presence of a NPM1 mutation in the absence of a FLT3 internal tandem duplication (or low level allele ratio) is associated with a more favourable prognosis in AML.

FLT3 (ITD and D835) mutation detection​ is also available for AML patients at diagnosis. 

 

For clinical advice on appropriate investigations and advice for the interpretation of test results, please contact us​.