Test Directory
HRAS mutation analysis
Containers - Adult
FFPE block / H&E slide / Pathology report
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Laboratory Site
Old Dalkeith Road
Edinburgh
EH16 4SA
Transport arrangements
Referral specimens should be sent directly to Molecular Pathology at the above address (see transport recommendations). For patients with pathology specimens held within NHS Lothian there is no need to arrange transport of specimens
How to request
HRAS mutation analysis can be requested individually or as part of the thyroid cancer panel
Testing for NHS Lothian patients can be requested by email to molecular.pathology@nhslothian.scot.nhs.uk. Referral requests must be accompanied by a completed request form.
Document
Molecular Pathology Request form v11_PDF.pdf
Please also refer to our detailed requesting instructions.
Availability
Monday - Friday. 09:00 – 17:00
Anticipated turnaround
An integrated Molecular Pathology report should be available within 10 working days. See results.
Static information/disclaimer
Next-Generation sequencing of HRAS is accredited to ISO 15189:2012
General additional information
The HRAS protein is a small GTPase involved in regulation of cellular proliferation, survival and differentiation. It frequently occurs as a mutated activated form in a number of different cancer types. KRAS mutation analysis is carried out as part of the thyroid cancer testing panel.
Analysis is carried out by Next Generation Sequencing to detect mutations in exons 2 and 3 of the HRAS oncogene, which account for the majority of clinically relevant ‘hot-spot’ mutations. Further details of the NGS panel and regions analysed can be found here.
For clinical advice on appropriate investigations, please contact our Molecular Pathology team.