Test Directory
POLE mutation analysis
Containers - Adult
FFPE block / H&E slide / Pathology report
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Volume Range
Referral FFPE specimens should be sent directly to Molecular Pathology at RIE If DNA has already been extracted, this may be sent to Molecular Pathology/HMDS at the WGH site. |
Laboratory Site
Old Dalkeith Road
Edinburgh
EH16 4SA
Edinburgh
EH4 2XU
Transport arrangements
Referral specimens should be sent directly to Molecular Pathology at the above address (see transport recommendations). For patients with pathology specimens held within NHS Lothian there is no need to arrange transport of specimens.
If DNA has already been extracted, this may be sent to Molecular Pathology/HMDS at the WGH site.
How to request
Testing for NHS Lothian patients can be requested by email to molecular.pathoogy@nhslothian.scot.nhs.uk.
Referral requests must be accompanied by a completed request form.
Please also refer to our detailed requesting instructions.
Availability
Monday - Friday. 09:00 – 17:00
Anticipated turnaround
An integrated Molecular Pathology report should be available within 10 working days. See results.
Static information/disclaimer
This test has been accredited to ISO15189. However, part of the procedure now makes use of an automated pipetting system which has been separately validated, but is not currently accredited to ISO 15189.
DNA extraction is performed at RIE and subsequent Sanger sequencing is performed at WGH.
Please note: alternative methodologies may be used. Full details will be included in all reports.
General additional information
Assessment of POLE (exons 9 to 14) is available for endometrial carcinoma and, along with assessment of TP53 and MMR/MSI, provides information regarding prognosis and therapy.
For clinical advice on appropriate investigations, please contact our Molecular Pathology team.