Test Directory

ZnT8

Containers - Adult

AAXXAANoImage.jpg
Sarstedt Monovette Serum Gel Tube (Brown Cap)
Volume Range

​4.9mls

Additive per Container

​Clotting activator/gel

Containers - Child

AAXXAANoImage.jpg
Sarstedt Monovette Serum Gel Tube (Brown Cap)
Volume Range

​4.9ml

Additive per Container

​Clotting activator/gel

Reference ranges

ZnT8 antibodies

​Normal <15 U/ml

Positive > 15 U/ml

ZnT8 Antibodies:

 

Interpretive guidance for ZnT8 autoantibodies tested in line with Diabetes pathway: (data from Pearson et al, Exeter lab data 2020)

 

Age < 30 years                 Strong Positive   ≥ 126 U/ml

                                           Weak Positive  ≥ 65 U/ml

                                           Equivocal 15- 64.9 U/ml

 

Age ≥ 30 years                  Strong positive ≥ 20 U/ml

                                             Weak positive ≥ 15 U/ml

Laboratory Site

RIE
51 Little France Crescent
Old Dalkeith Road
Edinburgh
EH16 4SA
Telephone: 0131 536 1000

How to request

​Trak, ICE, Clinical Immunology request form.

Diabetic screen tests can only be requested via Hospital referrals.

Availability

​Normal working hours 9am-5pm Mon-Fri.

Anticipated turnaround

​21 Days

 

General additional information

ZNT8 is a major autoantigen in development of autoimmunity against pancreatic β-cells leading to type 1 diabetes (T1D) in children and young adults (Wenzlau et al., 2007). A high amount of ZNT8 autoantibodies are frequently detected in the early stage of T1D. With disease progression, ZNT8 autoantibody titers drop significantly.