Test Directory
ZnT8
Containers - Adult
Sarstedt Monovette Serum Gel Tube (Brown Cap)
|
Volume Range
4.9mls
Additive per Container
Clotting activator/gel |
Containers - Child
|
Sarstedt Monovette Serum Gel Tube (Brown Cap)
|
Volume Range
4.9ml
Additive per Container
Clotting activator/gel |
Reference ranges
ZnT8 antibodies
Normal <15 U/ml
Positive > 15 U/ml
ZnT8 Antibodies:
Interpretive guidance for ZnT8 autoantibodies tested in line with Diabetes pathway: (data from Pearson et al, Exeter lab data 2020)
Age < 30 years Strong Positive ≥ 126 U/ml
Weak Positive ≥ 65 U/ml
Equivocal 15- 64.9 U/ml
Age ≥ 30 years Strong positive ≥ 20 U/ml
Weak positive ≥ 15 U/ml
Laboratory Site
Old Dalkeith Road
Edinburgh
EH16 4SA
How to request
Trak, ICE, Clinical Immunology request form.
Diabetic screen tests can only be requested via Hospital referrals.
Availability
Normal working hours 9am-5pm Mon-Fri.
Anticipated turnaround
21 Days
General additional information
ZNT8 is a major autoantigen in development of autoimmunity against pancreatic β-cells leading to type 1 diabetes (T1D) in children and young adults (Wenzlau et al., 2007). A high amount of ZNT8 autoantibodies are frequently detected in the early stage of T1D. With disease progression, ZNT8 autoantibody titers drop significantly.