Test Directory

NRAS mutation analysis

Containers - Adult

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FFPE block / H&E slide / Pathology report

Laboratory Site

RIE
51 Little France Crescent
Old Dalkeith Road
Edinburgh
EH16 4SA
Telephone: 0131 536 1000

Transport arrangements

​Referral specimens should be sent directly to Molecular Pathology at the above address (see transport recommendations). For patients with pathology specimens held within NHS Lothian there is no need to arrange transport of specimens.

How to request

NRAS mutation analysis can be requested individually or as part of the colorectal cancer panel.

Testing for NHS Lothian patients can be requested by email to molecular.pathology@nhslothian.scot.nhs.uk. Referral requests must be accompanied by a completed request form.

 

Please also refer to our detailed requesting instructions.

Availability

​​Monday - Friday. 09:00 – 17:00

Anticipated turnaround

​​An integrated Molecular Pathology report should be available within 10 working days. See results.

Static information/disclaimer

This pyrosequencing assay is accredited to ISO 15189. The NGS test is also accredited to ISO 15189:2012

General additional information

NRAS is member of the RAS family of small GTPases and is related to KRAS. Like KRAS, the NRAS gene can be mutated in a number of different cancer types. NRAS mutation analysis is carried out using NGS or pyrosequencing to detect mutations in exons 2 or 3 (codons 12, 13, 59 and 61) of the NRAS oncogene, which account for the majority of clinically relevant ‘hot-spot’ mutations in colorectal cancer and some melanomas.

​For clinical advice on appropriate investigations, please contact Dr Anca Oniscu:

Tel: 0131 242 7140