NRAS mutation analysis
Containers - Adult
FFPE block / H&E slide / Pathology report
Old Dalkeith Road
Referral specimens should be sent directly to Molecular Pathology at the above address (see transport recommendations). For patients with pathology specimens held within NHS Lothian there is no need to arrange transport of specimens.
How to request
NRAS mutation analysis can be requested individually or as part of the colorectal cancer panel.
Testing for NHS Lothian patients can be requested by email to firstname.lastname@example.org. Referral requests must be accompanied by a completed request form.
Monday - Friday. 09:00 – 17:00
An integrated Molecular Pathology report should be available within 10 working days. See results.
This pyrosequencing assay is accredited to ISO 15189. The NGS test is also accredited to ISO 15189:2012
General additional information
NRAS is member of the RAS family of small GTPases and is related to KRAS. Like KRAS, the NRAS gene can be mutated in a number of different cancer types. NRAS mutation analysis is carried out using NGS or pyrosequencing to detect mutations in exons 2 or 3 (codons 12, 13, 59 and 61) of the NRAS oncogene, which account for the majority of clinically relevant ‘hot-spot’ mutations in colorectal cancer and some melanomas.
For clinical advice on appropriate investigations, please contact Dr Anca Oniscu: