Test Directory
Anti-Mitochondrial Antibody
Containers - Adult
Sarstedt Monovette Serum Gel Tube (Brown Cap)
|
Volume Range
4.9mls
Additive per Container
Clotting activator/gel |
Containers - Child
|
Sarstedt Monovette Serum Gel Tube (Brown Cap)
|
Volume Range
4.9ml
Additive per Container
Clotting activator/gel |
Reference ranges
Positive results by IIF are reported as (+) borderline, + positive and ++ strongly positive.
ELISA results are reported as:
M2 Negative <20 units
M2 Equivocal 20.1 - 24.1 units
M2 Positive >25 units
Laboratory Site
RIE
51 Little France Crescent
Old Dalkeith Road
Edinburgh
EH16 4SA
Old Dalkeith Road
Edinburgh
EH16 4SA
Telephone: 0131 536 1000
Special instructions for collection
Serum samples only please.
How to request
Trak, ICE, Clinical Immunology request form.
Availability
Normal working hours 9am-5pm Mon-Fri.
Anticipated turnaround
14 Days for IIF (Anti-Mitochondrial antibody)
21 Days for ELISA (M2)
What happens if the result is positive or abnormal
Reviewed and authorised by Consultant Immunologist.
General additional information
Tested alongside GPC, SMA and LKM
These antibodies are associated with primary biliary cirrhosis/ autoimmune liver disease.
Tested by Indirect immunofluorescence (IIF) using sections of rat liver, kidney and stomach. This antibody is measured on a combined liver, kidney and stomach section and so the results for anti-gastric parietal cell antibodies and anti-smooth muscle antibodies will also be reported. If AMA are observed the sera are further tested using an M2-specific ELISA.
Anti-Mitochondrial antibodies of the M2 type are present in at least 90% of patients with PBC where they are considered diagnostic but can also be present in other autoimmune diseases such as Sjogrens syndrome, autoimmune thyroid disease, SLE or polymyositis. Can be associated with anti-smooth muscle antibodies in PBC/CAH overlap.
Non-M2 AMA antibodies can also be associated with PBC (M4, M8 & M9) but may also be indicative of syphilis, connective tissue diseases, cardiomyopathy and drug-induced hepatitis. Please note that the laboratory does not subtype non-M2 anti-mitochondrial antibodies.