Test Directory

Anti-Mitochondrial Antibody

Containers - Adult

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Sarstedt Monovette Serum Gel Tube (Brown Cap)
Volume Range

​4.9mls

Additive per Container

​Gel

Containers - Child

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Teklab Small White Cap
Volume Range

​Minimum 1ml

Additive per Container

​None

Reference ranges

Positive results are reported as (+) borderline, + positive and ++ strongly positive.

ELISA results are reported as:

M2 Negative 0-25 U/ml

M2 positive >25 U/ml

Laboratory Site

RIE
51 Little France Crescent
Old Dalkeith Road
Edinburgh
EH16 4SA
Telephone: 0131 536 1000

How to request

​Trak, ICE, Clinical Immunology request form.

Availability

Normal working hours 8.00am-5pm Mon-Fri.

Anticipated turnaround

The Turnaround time for this test is 2 weeks (10 working days).

What happens if the result is positive or abnormal

Reviewed and authorised by Consultant Immunologist.

General additional information

Tested alongside GPC, SMA and LKM
 
These antibodies are associated with primary biliary cirrhosis/ autoimmune liver disease.
 
Tested by Indirect immunofluorescence (IIF) usingsections of rat liver, kidney and stomach. This antibody is measured on a combined liver, kidney and stomach section and so the results for anti-gastric parietal cell antibodies and anti-smooth muscle antibodies will also be reported. If AMA are observed the sera are further tested using an M2-specific ELISA.
Anti-Mitochondrial antibodies of the M2 type are present in at least 90% of patients with PBC where they are considered diagnostic but can also be present in other autoimmune diseases such as Sjogrens syndrome, autoimmune thyroid disease, SLE or polymyositis. Can be associated with anti-smooth muscle antibodies in PBC/CAH overlap.
Non-M2 AMA antibodies can also be associated with PBC (M4, M8 & M9) but may also be indicative of syphilis, connective tissue diseases, cardiomyopathy and drug-induced hepatitis. Please note that the laboratory does not subtype non-M2 anti-mitochondrial antibodies.