​An Anti-dsDNA test is often useful diagnostically for patients who have antinuclear antibodies or clinical findings suggestive of SLE. the presence of Anti-dsDNA is one of the American Rheumatism Association criteria for SLE and the antibody is rarely found in high levels in patients with other connective tissue diseases. However Anti-dsDNA antibodies may also be seen in patients with overlap symptoms between SLE and other autoimmune diseases, as well as in autoimmune liver disease.