Test Directory

Anti-Proteinase 3 Antibody

Containers - Adult

Sarstedt Monovette Serum Gel Tube (Brown Cap)	Volume Range 4.9ml Additive per Container Clotting activator/gel

Containers - Child

Sarstedt Monovette Serum Gel Tube (Brown Cap)	Volume Range 4.9ml Additive per Container Clotting activator/gel

Reference ranges

Normal Range:

Negative <2.0 IU/ml

Equivocal 2.0-3.0 IU/ml

Positive >3.0 IU/ml

Laboratory Site

RIE

51 Little France Crescent
Old Dalkeith Road
Edinburgh
EH16 4SA

Telephone: 0131 536 1000

How to request

Trak, ICE, Clinical Immunology request form.

Availability

Normal working hours 9am - 5pm Mon-Fri

Anticipated turnaround

Urgent same day/next day service available. sample must be received in lab by 1pm Mon-Fri. Prior to sending a sample the lab must be contacted.

Non urgent samples 7 Days.

What happens if the result is positive or abnormal

Reviewed and authorised by Consultant Immunologist.

Any urgent results are telephoned directly to the requesting clinician.

If 'new' positive, the result is given to the Consultant Immunologist or Registrar to contact the requesting clinician.

General additional information

This test is performed in conjuction with Anti-MPO

Positive PR3 specificity is strongly suggestive of ANCA associated vasculitis. Clinical correlation is advised along with confirmation of diagnosis histologically (tissue biopsy) wherever possible. Depending on the clinical scenario, urgent treatment may be warranted (by way of immune suppression therapy/therapeutic plasmapheresis)

Negative ANCA does not exclude vasculitis, and if there is clinical concern about vasculitis a tissue biopsy for histological diagnosis remains the gold standard for diagnosis.