Test Directory
Anti-Neutrophil Cytoplasmic Antibody
Containers - Adult
Sarstedt Monovette Serum Gel Tube (Brown Cap)
|
Volume Range
4.9mls
Additive per Container
Clotting activator/gel |
Containers - Child
|
Sarstedt Monovette Serum Gel Tube (Brown Cap)
|
Volume Range
4.9ml
Additive per Container
Clotting activator/gel |
Reference ranges
Positive IIF results are reported as (+) borderline, + positive and ++ strongly positive.
In addition the following ANCA patterns are reported:
pANCA, cANCA, and Atypical ANCA. In addition the ANCA staining can be obscured by ANA staining. In this case the pattern is reported as INA (not interpreted due to ANA staining).
Laboratory Site
RIE
51 Little France Crescent
Old Dalkeith Road
Edinburgh
EH16 4SA
Old Dalkeith Road
Edinburgh
EH16 4SA
Telephone: 0131 536 1000
Special instructions for collection
Serum samples only please.
How to request
By prior arrangement, email the Immunology lab on ImmunologyLabs@nhslothian.scot.nhs.uk
Availability
Normal working hours 9am-5pm Mon-Fri. For urgent requests please see Anti-PR3 and Anti-MPO.
Anticipated turnaround
21 Days
What happens if the result is positive or abnormal
Reviewed and authorised by Consultant Immunologist.
General additional information
ANCA's are measured by IIF.
Positive ANCA with MPO or PR3 specificity is strongly suggestive of ANCA associated vasculitis. Clinical correlation is advised along with confirmation of diagnosis histologically (tissue biopsy) wherever possible. Depending on the clinical scenario, urgent treatment may be warranted (by way of immune suppression therapy/therapeutic plasmapheresis).
Negative ANCA does not exclude vasculitis, and if there is clinical concern about vasculitis a tissue biopsy for histological diagnosis remains the gold standard.